Acanthosis nigricans is a condition which results in thick, dark areas developing on the skin. It is also known as AN.
The exact cause of this acanthosis nigricans is unknown. It can be a genetic (inherited) condition. When inherited, it is not considered dangerous. However it is sometimes associated with obesity, diabetes, cancer and certain drugs. All of these conditions can be considered potentially dangerous.
You cannot prevent acanthosis nigricans if it is hereditary.
If it is caused by something like obesity, losing weight may control it. If it caused by certain drugs, stopping them may control the condition. However the drugs may be necessary for some other more serious condition, in which case there is little you can do.